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Ohnolog pairs of group 5 were significantly enriched for key functions (table S20), such as the processing of glutamine and production of the key antioxidant of glutathione, which has been linked to nitrogen cycling associated with symbiosis ( 38 , 39 )

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In addition to an increase in GSH in the current MDD group, we also observed an association between higher GSH levels and a decrease in positive mood, which remained significant after covarying for the fraction of grey matter within the voxel