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GIP receptor agonism improves adipose tissue insulin sensitivity through a pathway distinct from the GLP-1 mechanism, meaning tirzepatide may interrupt the insulin-androgen cascade at multiple biological nodes simultaneously

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Johnson B, Haymaker CL, Parra ER, Soto LMS, Wang X, Thomas JV, Dasari A, Morris VK, Raghav K, Vilar E, Kee BK, Eng C, Parseghian CM, Wolff RA, Lee Y, Lorenzini D, Laberiano-Fernandez C, Verma A, Lang W, Wistuba II, Futreal A, Kopetz S , Overman MJ