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PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer

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Extracellular GSH is degraded by the enzymes γ-glutamyl transpeptidase (γ-GT) and dipeptidases (DP) into its structural amino acids (Figure 2B), which, once into the cell, are reused for GSH synthesis [17]