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Keywords: Endometriosis, Endometrioma, Deep infiltrating endometriosis, Fibrosis, TGF-β, S1P Introduction Endometriosis is a chronic inflammatory and sex steroid hormone-dependent gynaecologic disease, characterized by endometrial cell proliferation outside the uterine cavity [1, 2], diagnosed in 6–10% of all reproductive-age women [3]

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The proposed sequence: BPC-157 → upregulated GHR → enhanced response to GH in the culture medium → increased fibroblast proliferation and collagen synthesis in vitro