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Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

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30 Even though chronic malnutrition is common among liver disease patients, there is a subset of malnourished patients, namely those with the psychiatric illness anorexia nervosa, which merits special attention