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Interestingly, most of the clock genes are expressed in the pars tuberalis with a 24h rhythmicity different from their expression in the SCN (49), and these clock genes are influenced by melatonin with numerous potential seasonal effects

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Mechanism of Action L-theanine exerts its effects through multiple pathways: Glutamatergic Modulation: Acts as a glutamate analog, binding to glutamate receptors and reducing excitatory signaling GABA Enhancement: Increases inhibitory neurotransmission, contributing to anxiolytic effects Dopamine and Serotonin Regulation: Supports mood stability and cognitive performance Alpha Brain Wave Activity: Promotes a state of relaxed wakefulness, as demonstrated in EEG studies Additionally, L-theanine has been shown to cross the blood-brain barrier, allowing for direct central nervous system effects