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The production of TNF-α depends on the activation of NF-κB signaling pathway stimulated by ROS, which in turn activates the p38/JNK signaling pathway to accelerate the progression of RA (41) ( Figure 2 )

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Sikirić P, Petek M, Rucman R, Seiwerth S, Grabarević Z, Rotkvić I, et al