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doi: 10.1080/15548627.2016.1203484 41 AlmeidaMHanLMartin-MillanMPlotkinLIStewartSARobersonPKet al

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Results obtained showed that the double knockdown of Dmrt3 and Dmrta2 upregulates the expression of proneural genes such as Neurog2 or Neurod1 that act as the primary initiators of neuronal differentiation and are directly activated by Pax6 , while the additional knockdown of Pax6 in Dmrt3