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It serves as the primary intracellular reducing agent for reactive oxygen species (ROS), a cofactor for glutathione peroxidase (GPx), and a central mediator of hepatic detoxification via glutathione S‑transferase (GST) and the γ‑glutamyl cycle

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When Trx is in a reduced state, Trx-(SH) 2 , the two active-site cysteines form a dithiol group that is able to catalyze the reduction of disulfides in a number of proteins