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Key Takeaways MK-677 (ibutamoren) is the only orally bioavailable peptidomimetic with multiple human RCTs showing reproducible IGF-1 elevation of roughly 40% to 70% above baseline at 10 to 25 mg daily

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M1 macrophages, induced by Toll-like receptor ligands (e.g., LPS) or Th1 cytokines such as TNF-α, IFN-γ, and colony-stimulating factor 2 (CSF2), are characterized by surface expression of TLR2, TLR4, CD80, and CD86 (84)