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HIF-1α inhibition (e.g., IDF-11774) in HCT116 cells suppresses LA and ATP production while elevating AMP/ATP ratios, confirming its glycolytic regulatory role [76]

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Native IGF-1 has a frustrating pharmacokinetic limitation: it binds tightly to a family of IGF binding proteins (IGFBPs, particularly IGFBP-3) that sequester it in circulation and keep its free half-life to roughly 15-20 minutes