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it is approximately 85% for boys with late testicular relapse.[225] Standard treatment options in North America for childhood ALL that has recurred in the testes include the following: Chemotherapy

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For example, due to the downregulation of genes for purinergic receptors (e.g., P2ry12 ) and potassium leak channels (e.g., Thik-1 ) in aged mice, the ability for microglia to sense hyperactive neurons and migrate toward them in order to facilitate rapid repolarization would be reduced, impairing their beneficial modulation (Hickman et al., 2013

and some have raised concerns about Consistency in effectiveness over time