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TGF-β plays a key role in renal fibrosis, leading to tubulointerstitial fibrosis and glomerulosclerosis by promoting the production of inflammatory factors and fibroblast proliferation

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555 Recent research has demonstrated promising approaches, such as encapsulating 2-aminothiophene derivatives in calcium carbonate microparticles to reduce systemic toxicity, 556 although potential immunogenicity risks associated with nanocarriers warrant careful consideration