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When a liposomal glutathione (L-GSH) supplement was given to Individuals with HIV with low CD4+ T cell counts, below 350 cells/mm 3 , over a 3-month period, there was a notable increase in levels of IL-2, IL-12, and IFN-γ, with a concomitant decrease in levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts [19]
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SIRT3 (widely expressed in mitochondria-rich tissues such as kidney, heart, brain, and liver tissue), is linked to age-related diseases, cancer, and heart and metabolic diseases, suggesting that it may be a potential therapeutic target [144]