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2.2 Immunosuppressive cells Regulatory T Cells (Tregs): In the TIME, the substantial enrichment of Tregs suppresses NK cell and CD8+ T cell activity through the massive secretion of immunosuppressive cytokines such as TGF-β, IL-35, and IL-10, which in turn suppress NK cell and CD8+ T cell activity ( FBXO38 ( These immunosuppressive cells interact through intricate mechanisms, forming a complex immunosuppressive network in the TME, which is crucial for tumor growth, progression, and resistance to immunotherapy
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In clinical practice, MIC+B12 is commonly given either intramuscularly (IM) or subcutaneously (SC) on a recurring schedule to support consistency