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Author Contributions Concept and design: Danny Kwon, Michelle Seu Acquisition, analysis, or interpretation of data: Danny Kwon, Sylvester Barnes, Michelle Seu Drafting of the manuscript: Danny Kwon, Michelle Seu Critical review of the manuscript for important intellectual content: Danny Kwon, Sylvester Barnes, Michelle Seu Supervision: Sylvester Barnes References 1.The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro

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Primary IGF-I deficiency can result from interruptions in GHR binding or activation, post-receptor signaling, or IGF-I gene expression