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Providing increasing doses of LT4 therapy The optimal treatment for hypothyroidism remains a subject of debate, with the etiology and severity of hypothyroidism and the amount of residual functional thyroid tissue affecting the LT4 dosage (23, 24) Moreover, in light of the complexities surrounding thyroid hormone homeostasis, a one-size-fits-all approach to TSH targets may be inappropriate, particularly given the interindividual variability in TSH set-points and peripheral hormone metabolism (8, 23, 25)

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