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Furthermore, PI-induced prelamin A build-up is directly linked to increased oxidative stress and lipodystrophy-associated symptoms ( Mitochondrial DNA quantity and quality are important factors in mitochondrial functionality, and therefore cellular fitness, as mtDNA encode for vital components of the organelle’s respiratory chain complexes

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Third, regulatory agencies should evaluate updates to prescribing information to reflect emerging safety signals meeting pharmacovigilance thresholds, while maintaining evidentiary standards for causal inference

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