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State-of-the-art co-folding methods, such as AlphaFold3, are computationally expensive to scale at the proteome level and struggle to predict novel MGD-mediated ternary complexes 47 , partly owing to the absence of evolutionary constraints in neomorphic interfaces

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Finally, BPC 157 therapy counteracts the anesthetic effect of thiopental in rats [218], a prototype member of the barbiturate class of drugs (Table 4)