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(More information) Low maternal vitamin B 12 status has been associated with an increased risk of neural tube defects (NTD), but it is not known whether vitamin B 12 supplementation could help reduce the risk of NTD

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However, a very small percentage of B12 from a supplemental dose is absorbed by passive diffusion, rather than by intrinsic factor, such that vegans can make up for taking B12 only once per day, or even only once per week, by taking larger doses than normally provided by food