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Another B12 shot side effect is diarrhea, though it’s usually pretty mild

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In vivo experiments have demonstrated that betaine activates adenosine monophosphate-activated protein kinase subunit alpha 1 (AMPKα1), upregulating fatty acid oxidation, citric acid cycle, and mitochondrial oxidative phosphorylation, thereby accelerating lipid consumption and limiting weight gain (33, 34) (Figure 3A)