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extensive safety and efficacy data Healthy elderly adults – Research populations examining age-related hormone decline Adults with documented growth hormone deficiency – Limited studies in pathological deficiency states Elderly subjects with low IGF-1 levels – Targeted populations for hormone restoration trials Male and female adult subjects – Gender-comparative studies showing differential responses Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite FDA approval for pediatric growth hormone deficiency diagnosis and treatment from 1997-2008, sermorelin faces substantial evidence gaps limiting broader applications