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These Schiff bases go through complex reactions to form advanced AGEs, which cause tissue destruction through the formation of cross-links that alter the protein structure and function and relations with cell surface receptors on endothelial cells and macrophages, which contributes to the activation of cell signaling and gene expression that induce oxidative stress and inflammation in DM (Spadaccio et al., 2014

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Salutary effect of gastric pentadecapeptide BPC 157 in two different stress urinary incontinence models in female rats