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Overall, changes in these pharmacodynamic parameters were consistent with pharmacokinetics within each group and did not reveal any significant differences in the pharmacodynamic response to apixaban between Japanese and Caucasian subjects
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Intact mass by electrospray establishes the molecular species, and tandem mass spectrometry establishes the sequence, and both are worth having because for a peptide of this size the intact mass alone does not distinguish sequence isomers or positional variants
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