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Feeding both precursors together keeps the whole line moving, which is the reasoning behind the combined approach used in the clinical research on this pairing (1)

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Rescuing IOC with amlodipine in the animal model As an L-type Ca 2+ channel blocker, amlodipine can reduce the entry of non-transferrin-bound iron (Fe 2+ ) via L-type Ca 2+ channels, resulting in lower levels of cardiac iron and reduced oxidative stress in cardiac tissue